RNA Details
Disease Name
cystic fibrosis
Tissue
pancreas
RNA Symbol
mir-15
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
RT-PCR; immunofluorescence etc.
Target
BCL-2; SMAD 5
Pathway
TGF-BETA SIGNALING PATHWAY; SMADS SIGNALING PATHWAY
PubMed ID
Title
HDAC inhibitors promote pancreatic stellate cell apoptosis and relieve pancreatic fibrosis by upregulating miR-15/16 in chronic pancreatitis
Year
2020
Function
"These results suggested that hdac inhibition protects against cp by promoting apoptosis and tgf-beta;Smads signaling pathways, and indicated that hdac inhibition is a potential therapy to alleviate cp patients in clinic, and these need to be explored further."